Hedgehog Signaling Is Critical for Normal Liver Regeneration After Partial Hepatectomy in Mice

• DOI: 10.1002/hep.23525
• Publication Date: 2010-01-15T20:11:07Z
• Authors: Begoña Ochoa; Wing-Kin Syn; Igotz Delgado; Gamze F. Karaca; Youngmi Jung; Jiangbo Wang; Ana M. Zubiaga; Olatz Fresnedo; Alessia Omenetti; Marzena Zdanowicz; Steve S. Choi; Anna Mae Diehl
• Keywords: Liver Regeneration; Organogenesis; Progenitor

Distinct mechanisms are believed to regulate growth of the liver during fetal development and after injury in adults, because former relies on progenitors latter generally involves replication mature hepatocytes. However, chronic adults increases production Hedgehog (Hh) ligands, developmental morphogens that control progenitor cell fate orchestrate various aspects tissue construction embryogenesis. This raises possibility similar Hh-dependent also might adult regeneration. The current analysis murine regeneration 70% partial hepatectomy (PH), an established model regeneration, demonstrated PH induced Hh ligands activated signaling cells. Treatment with a specific inhibitor interfered several key components normal significantly inhibiting responses, matrix remodeling, proliferation hepatocytes ductular cells, restoration mass. These global inhibitory effects dramatically reduced survival PH. Conclusion: Mechanisms mediate organogenesis, such as pathway activation, retained promote reconstruction livers injury. Hepatology 2010