Hypoxia-inducible MicroRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma

• DOI: 10.1002/hep.24614
• Publication Date: 2011-08-16T20:38:23Z
• Authors: Qiao Ying; Linhui Liang; Weijie Guo; Ruopeng Zha; Qi Tian; Shenglin Huang; Jian Yao; Jie Ding; Meiyan Bao; Chao Ge; Ming Yao; Jinjun Li; Xianghuo He
• Keywords: Hypoxia

Abstract As the “master” microRNA that is induced by hypoxia, miR-210 involved in multiple processes hypoxia pathway. However, whether mediates hypoxia-induced tumor cell metastasis still remains unclear. Here, we demonstrate frequently up-regulated hepatocellular carcinoma (HCC) samples and promotes migration invasion of HCC cells. Furthermore, can be cells metastasis. We identify vacuole membrane protein 1 (VMP1) as direct functional downstream target miR-210; addition, show its expression negatively correlated with HCC. Intriguingly, VMP1 reduced down-regulation Conclusion: These findings extend our understanding function pathway, this newly identified hypoxia/miR-210/VMP1 pathway should facilitate development novel therapeutics against hypoxic (Hepatology 2011)