Mutual Interaction Between Yap And Creb Promotes Tumorigenesis in Liver Cancer

• DOI: 10.1002/hep.26420
• Publication Date: 2013-03-26T17:37:17Z
• Authors: Jiayi Wang; Lifang Ma; Wenhao Weng; Yongxia Qiao; Yue Zhang; Jiangtu He; Hongmei Wang; Weifan Xiao; Lanlan Li; Qinghua Chu; Qiuhui Pan; Yongchun Yu; Fenyong Sun
• Keywords: Liver Cancer

Yes-associated protein (YAP), the downstream effecter of Hippo-signaling pathway as well cyclic adenosine monophosphate response element-binding (CREB), has been linked to hepatocarcinogenesis. However, little is known about whether and how YAP CREB interact with each other. In this study, we found that YAP-CREB interaction critical for liver cancer cell survival maintenance transformative phenotypes, both in vitro vivo . Moreover, proteins are highly expressed a subset human samples closely correlated. Mechanistically, promotes transcriptional output through binding −608/−439, novel region from promoter. By contrast, stabilization mitogen-activated kinase 14 (MAPK14/p38) beta-transducin repeat containing E3 ubiquitin ligase (BTRC). Gain-of-function loss-of-function studies demonstrated phosphorylation by MAPK14/p38 at ser133 ultimately leads its degradation. Such effects can be enhanced BTRC Thr180/Tyr182. negatively controls inhibition expression. Conclusion : There positive autoregulatory feedback loop underlying between cancer, suggesting form nexus integrate A, Hippo/YAP, pathways cells thus may helpful development effective diagnosis treatment strategies against cancer. (Hepatology 2013;53:1011–1020)