Pericentral hepatocytes produce insulin‐like growth factor‐2 to promote liver regeneration during selected injuries in mice

• DOI: 10.1002/hep.29340
• Publication Date: 2017-06-27T12:12:47Z
• Authors: Junlai Liu; Xiao Hu; Jie Chen; Xinqi Li; Lu Wang; Binbin Wang; Wenbo Peng; Cuiwei Yang; Zhijie Li; Yan Chen; Yue J. Wang; Chuanjiang Li; Xiajun Li; Fang Yan; Yunfang Wang; Changzhen Shang; Xin Wang; Tao Chen; Pengyu Huang
• Keywords: Liver Regeneration; Lobules of liver

Liver regeneration (LR) happens after various types of injuries. Unlike the well‐studied LR caused by partial hepatectomy (PHx), there is accumulating evidence suggesting that during other injuries may result from unknown mechanisms. In this study, we found insulin‐like growth factor 2 (IGF‐2) was drastically induced following liver tyrosinemia or long‐term treatments CCl 4 . However, not observed early phase acute PHx single treatment Remarkably, most IGF‐2‐expressing hepatocytes were located at histological area around central vein lobule either in fumarylacetoacetate hydrolase–deficient mice chronically treated mice. Hepatocyte proliferation vivo significantly promoted IGF‐2 overexpression, which could be inhibited adeno‐associated virus–delivered short hairpin RNAs linsitinib, an inhibitor signaling. Proliferating responded to through both insulin receptor and IGF‐1 receptor. also DNA synthesis primary vitro More interestingly, colocalize with glutamine synthetase region enriched proliferating for samples patients fibrosis. Conclusion: produced pericentral promote hepatocyte repair tissue damage setting chronic injury, distinct signaling occurs post‐PHx. (H epatology 2017;66:2002–2015)