CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein–Coupled Receptor–Mediated Signaling in Hepatocellular Carcinoma

• DOI: 10.1002/hep.30068
• Publication Date: 2018-04-28T00:53:59Z
• Authors: Yin Yin; Xiaoliang Xu; Junwei Tang; Wenjie Zhang; Guangyan Zhangyuan; Jie Ji; Lei Deng; Shuai Lu; Han Zhuo; Beicheng Sun
• Keywords: Internalization

Cluster of differentiation 97 (CD97) is a member the epidermal growth factor seven-transmembrane family belonging to class B G protein-coupled receptors (GPCRs). The protein affects tumor aggressiveness through its cellular ligand CD55 stimulation and exhibits adhesive properties. Studies have demonstrated involvement CD97 in dedifferentiation, migration, invasiveness, metastasis tumors. However, little information currently available on specific role hepatocellular carcinoma (HCC). Here, we shown that up-regulation HCCs positively correlated with metastasis. Functionally, promoted cell migration invasion vitro. In an vivo mouse model, overexpression HCC cells led accelerated lung Mechanistically, cooperated altered regulator, GPCR kinase 6 (GRK6), mediate desensitization internalization. Down-regulation GRK6 suppressed internalization expression. Integrated regulatory interactions between stimulated downstream matrix metalloproteinase 2/9 secretion and, consequently, Conclusion: Our collective findings support utility as effective potential prognosticator therapeutic target for HCC.