CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice

• DOI: 10.1002/hep.30919
• Publication Date: 2019-08-30T09:34:07Z
• Authors: Zhimin Hu; Yamei Han; Yuxiao Liu; Zehua Zhao; Fengguang Ma; Aoyuan Cui; Feifei Zhang; Zhengshuai Liu; Yaqian Xue; Jinyun Bai; Haifu Wu; Hua Bian; Y. Eugene Chin; Ying Yu; Zhuoxian Meng; Hua Wang; Yong Liu; Jiangao Fan; Xin Gao; Yan Chen; Yu Li
• Keywords: Liver Regeneration

STAT3, a member of the signal transducer and activator transcription (STAT) family, is strongly associated with liver injury, inflammation, regeneration, hepatocellular carcinoma development. However, signals that regulate STAT3 activity are not completely understood.Here we characterize CREB/ATF bZIP factor CREBZF as critical regulator in hepatocyte to repress regeneration. We show deficiency stimulates expression cyclin gene family enhances regeneration after partial hepatectomy. Flow cytometry analysis reveals regulates cell cycle progression during hepatocyte-autonomous manner. Similar results were observed another model induced by intraperitoneal injection carbon tetrachloride (CCl4 ). Mechanistically, potently associates linker domain represses its dimerization transcriptional vivo vitro. Importantly, hepatectomy-induced hyperactivation D1 liver-specific knockout mice was reversed selective inhibitor cucurbitacin I. In contrast, adeno-associated virus-mediated overexpression inhibits attenuates CCl4 -treated mice.These coregulator inhibit regenerative capacity, which may represent an essential cellular maintain mass homeostasis. Therapeutic approaches benefit compromised transplantation.