Effect of Interferon Therapy on Hepatocellular Carcinogenesis in Patients With Chronic Hepatitis Type C: A Long–Term Observation Study of 1,643 Patients Using Statistical Bias Correction With Proportional Hazard Analysis

• DOI: 10.1002/hep.510290439
• Publication Date: 2004-07-28T07:45:08Z
• Authors: Kenji Ikeda; Satoshi Saitoh; Yasuji Arase; Kazuaki Chayama; Yoshiyuki Suzuki; Masahiro Kobayashi; Akihito Tsubota; Mizuho Kobayashi; Ikuo Nakamura; Naoya Murashima; Hiromitsu Kumada; Masahiro Kawanishi
• Keywords: Hepatitis C

The activity of interferon (IFN) is not elucidated from the viewpoint cancer prevention in chronic hepatitis C patients en masse. hepatocellular carcinogenesis rate was analyzed statistically 1,643 with C: 1,191 IFN therapy and 452 without therapy. Hepatocellular rates treated untreated groups were 2.1% 4.8% at end 5th year, 7.6% 12.4% 10th respectively (P =.0036). Multivariate analysis showed that slightly decreased risk by 33%, compared =. 14), adjusting for confounding effects age, fibrotic stage, gender, gamma-glutamyl transpeptidase (GGTP) value. Among IFN, 461 attained persistent loss virus (HCV) RNA, other 145 retained normal alanine transaminase (ALT) values HCV RNA. hazard these 606 ALT or HCV-RNA clearance significantly lower than (hazard ratio: 0.32; P =.012) abnormal aminotransferase group. C, those low values.