Parallel reductions of IgE and exhaled nitric oxide after optimized anti‐inflammatory asthma treatment
corticosteroid
Medicin och hälsovetenskap
leukotriene-receptor antagonist
breath test
atopy
Immunoglobulin E
Nitric Oxide
Medical and Health Sciences
Asthma
asthma control
immunoglobulin E
3. Good health
03 medical and health sciences
0302 clinical medicine
quality of life
Breath Tests
Exhalation
Quality of Life
Humans
Anti-Asthmatic Agents
FENO
Original Research
Follow-Up Studies
DOI:
10.1002/iid3.103
Publication Date:
2016-03-21T09:03:01Z
AUTHORS (7)
ABSTRACT
Abstract Immunoglobulin E (IgE) is crucial for the development of airway inflammation in atopic asthma, and inhibition IgE using monoclonal antibodies now part asthma therapy. However, impact ordinary anti‐inflammatory treatment on unclear. The aim this study was to investigate if optimization with inhaled corticosteroid (ICS) leukotriene‐receptor antagonist (LTRA) according symptoms or exhaled nitric oxide (F NO) levels over a one‐year period affects concentrations. Altogether, 158 relatively well‐controlled but multi‐sensitized asthmatics (age 18–65 years), ongoing ICS at baseline, were included post hoc analysis data from randomized, controlled trial F NO‐guided Asthma control quality life (Juniper ACQ mAQLQ), NO, serum measured baseline after one year. Concentrations six common perennial aeroallergens summed up (perennial IgE). We found that total decreased by 10.2% 16.0% ( P < .001 both comparisons). This not related allergen exposure, whereas use LTRA during year correlated reduction = .030 .013). decrease significantly NO .003 .001), improvements mAQLQ scores 0.05, all conclude patients persistent resulted significant decreases antibodies; these life. Thus, reduced controller medications effect seems be clinically important.
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