Retrospective, observational study of different medication regimens and outcome in children with cough variant asthma

• DOI: 10.1002/iid3.1357
• Publication Date: 2024-08-07T14:28:41Z
• Authors: Nannan Lou; Xiang Ma; Qingxin Luo; Xiaoling Wei; Yun Zhang; Jing Guo; Jing Wang; Zhongtao Gai
• Keywords: Male; Adolescent; 03 medical and health sciences; 0302 clinical medicine; children; Adrenal Cortex Hormones; treatment strategy; Administration, Inhalation; cough variant asthma; Humans; Anti-Asthmatic Agents; Longitudinal Studies; Child; Adrenergic beta-2 Receptor Agonists; Retrospective Studies; Cough-Variant Asthma; RC581-607; Asthma; Treatment Outcome; Cough; Child, Preschool; Leukotriene Antagonists; Original Article; Female; Drug Therapy, Combination; Immunologic diseases. Allergy

Abstract Objective This retrospective longitudinal cohort study aimed to explore the best therapeutic regimen and treatment duration of cough variant asthma (CVA) in children. Methods A total 314 children with CVA were divided into receive inhaled corticosteroids (ICS) combined long‐acting beta2‐agonist (LABA) group, ICS leukotriene receptor antagonists (LTRA) monotherapy group LTRA group. All clinical data statistically analyzed. Logistic regression model was used compare advantages disadvantages different schemes at each follow‐up time point scheme. The Cox proportional hazard based on inverse probability weighting effects medication regimens adverse outcomes recurrence or progression as end point. Results (1) After comprehensive analysis, + LABA preferred control for within 8 weeks. weeks diagnosis, efficacy comparable that (2) showed a significant improvement an early stage, particularly 4 weeks; symptoms groups significantly improved 36 alone 20 Conclusion LABA, LTRA, can effectively treat CVA. could improve most quickly after followed by LATR weeks, it be reduced least remission