Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

• DOI: 10.1002/ijc.20724
• Publication Date: 2004-11-18T16:48:45Z
• Authors: Young‐Woon Chang; Jae‐Young Jang; Nam‐Hoon Kim; Jae Won Lee; Hyo Jung Lee; Woon Won Jung; Seok‐Ho Dong; Hyo‐Jong Kim; Byung‐Ho Kim; Joung‐Il Lee; Rin Chang
• Keywords: Linkage Disequilibrium

Abstract Interleukin‐1B and IL‐1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL‐1B ‐511T polymorphism the GC Asians. We tested for loci mucosal levels IL‐1β developing a Korean population. Polymorphisms IL‐1A ‐889, ‐31, ‐511 IL‐1RN were genotyped 434 controls 234 patients GC. Mucosal cytokine was measured using ELISA. The frequencies IL‐1A, ‐511, ‐31 statistically different all After subclassification GC, only intestinal‐type showed higher frequency ‐31T homozygotes (OR = 2.2; 95% CI 1.1–4.3) compared controls. Risk also significantly these diffuse‐type 3.4; 1.5–7.7). As populations, linkage disequilibrium nearly complete, but pattern haplotype related to ( ‐31T/ ‐511C) opposite ‐511T/ ‐31C). H. pylori ‐infected homozygous ‐31C/T ‐31C/C. Thus, combined effects infection ‐511C enhanced production contributed development this © 2004 Wiley‐Liss, Inc.