DNA repair deficiency leads to susceptibility to develop arsenic‐induced premalignant skin lesions

• DOI: 10.1002/ijc.23478
• Publication Date: 2008-04-03T22:17:34Z
• Authors: Mayukh Banerjee; Nilendu Sarma; Rupanwita Biswas; Jyoeeta Roy; Anita Mukherjee; Ashok K. Giri
• Keywords: Comet Assay; Keratosis; Arsenic toxicity

Abstract In West Bengal, India, although more than 6 million people are exposed to arsenic through drinking water, only 15–20% showed arsenic‐induced skin lesions, including premalignant hyperkeratosis. This indicates toward some factors that confer susceptibility carcinogenicity. this work, we wanted explore whether differences in DNA repair capacity could impart carcinogenicity, Comet assay, chromosomal aberration (CA) assay and challenge assay. Sixty (30 individuals with hyperkeratosis 30 without lesion, but similar contaminated water) unexposed were recruited as study participants. Alkaline comet carried out whole blood CA lymphocytes find the damage both hyperkeratotic lesion individuals. well found be significantly higher arsenic‐exposed compared ( p < 0.001). Within group, there was no significant difference far level of is concerned > 0.05), 0.01). Challenge upon induction damage, less 0.001) basal both. Thus, deficiency capacities emerges a prime contender for © 2008 Wiley‐Liss, Inc.