Upregulation of miR‐23a∼27a∼24 decreases transforming growth factor‐beta‐induced tumor‐suppressive activities in human hepatocellular carcinoma cells

• DOI: 10.1002/ijc.23580
• Publication Date: 2008-05-28T19:48:56Z
• Authors: Shenglin Huang; Xianghuo He; Jie Ding; Linhui Liang; Yingjun Zhao; Zhenfeng Zhang; Xiao Yao; Zhimei Pan; Pingping Zhang; Jinjun Li; Dafang Wan; Jianren Gu
• Keywords: Liver Cancer

Transforming growth factor-beta (TGF-beta) plays a dual and complex role in human cancer. In this report, we observe specific set of MicroRNAs (miRNAs) changed response to TGF-beta hepatocellular carcinoma (HCC) cells by miRNA microarray screening. A cluster miRNA, miR-23a approximately 27a 24, is induced an early stage Huh-7 cells. Knockdown Smad4, Smad2 or Smad3 expression RNA interference can attenuate the 24 addition, indicating that induction dependent on Smad pathway. We also explore function as antiapoptotic proliferation-promoting factor liver cancer found be remarkably upregulated HCC tissues versus normal tissues. These findings suggest novel, alternative mechanism through which could induce escape from tumor-suppressive