Tuberculosis and subsequent risk of lung cancer in Xuanwei, China

• DOI: 10.1002/ijc.24042
• Publication Date: 2008-12-04T09:33:28Z
• Authors: Eric A. Engels; Min Shen; Robert S. Chapman; Ruth M. Pfeiffer; Ying‐Ying Yu; Xingzhou He; Qing Lan
• Keywords: Adult; Inflammation; Male; Risk; Lung Neoplasms; Pulmonary Fibrosis; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Humans; Tuberculosis; Female

Abstract Tobacco and indoor air pollution from smoky coal are major causes of lung cancer in rural Xuanwei County, China. Tuberculosis has been suggested to increase risk, but data prior studies limited. We conducted an analysis a retrospective cohort study 42,422 farmers Xuanwei. In 1992, interviewers administered standardized questionnaire that included lifetime medical history, including tuberculosis. Subjects were followed 1976, with deaths ascertained through 1996. used proportional hazards regression assess the association between tuberculosis subsequent mortality. was reported by 246 subjects (0.6%), 2,459 (5.8%) died during follow‐up. Lung mortality substantially higher than those without (25 vs . 3.1 per 1,000 person‐years). The especially pronounced first 5 years after diagnosis (hazard ratios [HRs] ranging 6.7–13) remained strong 5–9.9 (HR 3.4, 95% CI 1.3–9.1) 10+ 3.0, 1.3–7.3) These associations similar among men women users (70.5% subjects). Adjustment for demographic characteristics, disease tobacco use did not affect results. Xuanwei, China, is important risk factor cancer. increased persisting diagnosis, could reflect effects chronic pulmonary inflammation scarring arising Published 2008 Wiley‐Liss, Inc.