Doxorubicin and mitoxantrone drug eluting beads for the treatment of experimental peritoneal carcinomatosis in colorectal cancer

• DOI: 10.1002/ijc.24211
• Publication Date: 2008-12-09T22:26:40Z
• Authors: Michael Keese; Lala Gasimova; Kay Schwenke; Vugar Yagublu; Edward Shang; Ralf Faissner; Andrew Lewis; Stefan Samel; Matthias Löhr
• Keywords: Mitoxantrone

Abstract We investigated the therapeutic efficiency of sulfonate‐modified polyvinyl alcohol beads loaded with doxorubicin, irinotecan or mitoxantrone in vitro and vivo a model experimental peritoneal carcinomatosis (PC). In , cell proliferation was efficiently impaired by doxorubicin drug eluting bead (DEB) treatment while DEBs were less effective than. Irinotecan showed little effect for both free drug. Apoptosis not different between DEB form more apoptosis induction observed cells incubated irinotecan. Experimental PC produced mice. The either drugs compared. Mice treated once on day 12 3 repetitive applications days 7, 10 12. weight loss mortality. Therapeutic determined measuring tumor volume load 15 after inoculation. For single application 12, an advantage could be drugs. After repeated injections no difference observed. Least mice that received DEB. No animal survived doxorubicin. conclude encapsulation chemotherapeutic may show toxicity spread colorectal cancer. © 2008 Wiley‐Liss, Inc.