Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels

• DOI: 10.1002/ijc.24591
• Publication Date: 2009-05-26T15:23:03Z
• Authors: Kimihiko Yanaoka; Masashi Oka; Hiroshi Ohata; Noriko Yoshimura; Hisanobu Deguchi; Chizu Mukoubayashi; Shotaro Enomoto; Izumi Inoue; Mikitaka Iguchi; Takao Maekita; Kazuki Ueda; Hirotoshi Utsunomiya; Hideyuki Tamai; Mitsuhiro Fujishiro; Masataka Iwane; Tatsuya Takeshita; Osamu Mohara; Masao Ichinose
• Keywords: Atrophic gastritis; Pepsin; Spirillaceae; Stomach cancer

Abstract A longitudinal cohort study was conducted in Helicobactor pylori‐ infected middle‐aged Japanese males to evaluate the preventive effects of H. pylori eradication on development gastric cancer according extent chronic atrophic gastritis (CAG). The CAG monitored by baseline serum pepsinogen (PG) levels. We followed 3,656 subjects with persistent infection and 473 successful for a mean (SD) 9.3 (0.7) years. Groups without extensive were categorized based PG test‐positive criteria detect I ≤ 70 ng/ml I/II ratio 3.0. During period, 5 55 cancers developed ‐eradicated noneradicated subjects, respectively, indicating no significant reduction incidence after eradication. Among 1,329 2,327 test‐negative. Gastric confirmed 30 25 respectively. whose eradicated, 155 318 Of these 3 2 Significant observed only test‐negative ( p < 0.05; log‐rank test). results this strongly indicate that depends presence before is beneficial most mild as defined aforementioned criteria. © 2009 UICC