Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length

• DOI: 10.1002/ijc.29101
• Publication Date: 2014-07-28T09:53:38Z
• Authors: Daniele Campa; Alessandro Martino; Judit Varkonyi; Fabienne Lesueur; Krzysztof Jamroziak; Stefano Landi; Artur Jurczyszyn; Herlander Marques; Vibeke Andersen; Manuel Jurado; Hermann Brenner; Mario Petrini; Ulla Vogel; Ramón García‐Sanz; Gabriele Buda; Federica Gemignani; Rafael Ríos; Annette Juul Vang...; Charles Dumontet; Joaquín Martínez‐...; María José Moreno; Anna Stępień; Marzena Wątek; Victor Moreno; Aida Karina Dieff...; Anna Maria Rossi; Katja Butterbach; Svend E. Hove Jac...; Hartmut Goldschmidt; Juan Sainz; Jens Hillengass; Enrico Orciuolo; Marek Dudziński; Niels Weinhold; Rui Manuel Reis; Federico Canzian
• Keywords: Quartile

Compelling biological and epidemiological evidences point to a key role of genetic variants the TERT TERC genes in cancer development. We analyzed variability these two gene regions using samples 2,267 multiple myeloma (MM) cases 2,796 healthy controls. found that variant, rs2242652, is associated with reduced MM susceptibility (OR = 0.81; 95% CI: 0.72–0.92; p 0.001). In addition we measured leukocyte telomere length (LTL) subgroup 140 who were chemotherapy‐free at time blood donation 468 controls, patients had longer telomeres compared controls 1.19; 0.63–2.24; trend 0.01 comparing quartile longest LTL versus shortest LTL). Our data suggest hypothesis decreased disease risk by reduce efficiency telomerase complex. This leads shorter ends, which turn may also be marker risk.