Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort

• DOI: 10.1002/ijc.31991
• Publication Date: 2018-11-14T05:40:27Z
• Authors: Ai‐Ping Fang; Pei‐Yan Chen; Xiao‐Yan Wang; Zhao‐Yan Liu; Dao‐Ming Zhang; Yun Luo; Gong‐Cheng Liao; Jing‐An Long; Rong‐Huan Zhong; Zhong‐Guo Zhou; Yan‐Jun Xu; Xiao‐Jun Xu; Wen‐Hua Ling; Min‐Shan Chen; Yao‐Jun Zhang; Hui‐Lian Zhu
• Keywords: Liver Cancer

Copper and zinc are essential micronutrients, whose imbalance may be involved in the development progression of cancer. However, role copper and/or prognosis hepatocellular carcinoma (HCC) is currently unclear. Our objective was to investigate association between serum levels copper, their ratio (copper/zinc) at diagnosis with HCC survival. We included 989 patients incident this prospective cohort study, who were enrolled Guangdong Liver Cancer Cohort (GLCC) study within 30 days September 2013 February 2017. Serum measured using inductively coupled plasma mass spectrometry. Primary outcomes liver cancer‐specific survival (LCSS) overall (OS). Cox proportional hazards models used calculate multivariable hazard ratios (HRs) 95% confidence interval (CI). Higher strongly associated worse LCSS (Q4 vs . Q1: HR = 1.87, CI: 1.22–2.86; p < 0.01 for trend) OS 2.06, 1.36–3.11; trend). The calculated copper/zinc positively 1.31, 0.89–1.92; P 0.04 1.43, 0.99–2.08; No associations observed or entire cohort. results suggest that higher relation (i.e., ratio) survival, but not