Breast cancer survival in sub‐Saharan Africa by age, stage at diagnosis and human development index: A population‐based registry study

• DOI: 10.1002/ijc.32406
• Publication Date: 2019-05-14T15:11:58Z
• Authors: Walburga Y. Joko‐Fru; Adalberto Miranda...; Isabelle Soerjoma...; Marcel Egue; Marie‐Therese Ake...; Guy N'da; Mathewos Assefa; Nathan Buziba; Anne Korir; Bakarou Kamate; Cheick Traore; Shyam Manraj; Cesaltina Lorenzoni; Carla Carrilho; Rolf Hansen; Anne Finesse; Ntuthu Somdyala; Henry Wabinga; Tatenda Chingonzoh; Margaret Borok; Eric Chokunonga; Biying Liu; Eva Kantelhardt; Paul McGale; Donald M. Parkin
• Keywords: FOS: Political science; Social Sciences; Kaplan-Meier Estimate; Health Services Accessibility; Global Trends in Colorectal Cancer Research; Breast Cancer Screening; Breast cancer; 0302 clinical medicine; Sociology; Global Cancer Incidence and Mortality Patterns; Breast; Registries; Internal medicine; Political science; Cancer; Economic Burden of Cancer Treatment; Age Factors; Middle Aged; Cancer registry; Quality Improvement; FOS: Sociology; 3. Good health; Survival Rate; Economics, Econometrics and Finance; Environmental health; Oncology; Medicine; Female; Cancer Epidemiology; Economics and Econometrics; Human Development Index; Population; 610; Breast Neoplasms; FOS: Law; 613; Relative survival; survival; Risk Assessment; 03 medical and health sciences; breast cancer; Health Sciences; Humans; Biology; Africa South of the Sahara; Neoplasm Staging; Demography; Paleontology; stage; Human development (humanity); Socioeconomic Factors; human development index; Law; Stage (stratigraphy); Follow-Up Studies

Breast cancer is the leading diagnosis and second most common cause of deaths in sub-Saharan Africa (SSA). Yet, there are few population-level survival data from none on differences by stage at diagnosis. Here, we estimate breast within SSA area, country-level human development index (HDI). We obtained a random sample 2,588 incident cases, diagnosed 2008-2015 14 population-based registries 12 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mali, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda Zimbabwe) through African Cancer Registry Network. Of these, 2,311 were included for analyses. The 1-, 3- 5-year observed relative (RS) estimated registry, HDI. equally excess hazards adjusting potential confounders. Among patients with known stage, 64.9% late stages, 18.4% being metastatic RS varied ranging 21.6%(8.2-39.8) Year 3 Bulawayo to 84.5% (70.6-93.5) Namibia. Patients early stages had 3-year 78% (71.6-83.3) contrast 40.3% (34.9-45.7) advanced (III IV). overall 1 was 86.1% (84.4-87.6), 65.8% (63.5-68.1) 59.0% (56.3-61.6) 5. Age not independently associated increased mortality risk after effect In conclusion, downstaging improving access quality care could be pivotal outcomes Africa.