Trends in hysterectomy‐corrected uterine cancer mortality rates during 2002 to 2015: mortality of nonendometrioid cancer on the rise?

• DOI: 10.1002/ijc.33219
• Publication Date: 2020-07-19T15:30:30Z
• Authors: Line W. Gustafson; Berit B. Booth; Johnny Kahlert; Gitte Ørtoft; Else Mejlgaard; Megan A. Clarke; Nicolas Wentzensen; Anne F. Rositch; Anne Hammer
• Keywords: Corpus Uteri; Uterine cancer

Corpus uteri cancer is the most common gynecological malignancy in developed countries. The disease typically diagnosed at an early stage, of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates corpus cancer, overall stratified by age, stage subtype. Using data from nationwide Danish registries, calculated uncorrected age-standardized among women ≥35 years during 2002 to 2015. Individual-level hysterectomy status was obtained national registries; were subtracting posthysterectomy person-years denominator, unless performed due cancer. Correction for resulted 25.5% higher rate (12.3/100000 vs 9.8/100000 person-years). Mortality highest aged 70+, irrespective year death, subtype stage. A significant decline observed 2015, particularly 70+. declined significantly over time (annual percent change [APC]: -2.32, 95% CI -3.9, -0.7, P = .01), whereas nonendometrioid increased (APC: 5.90, CI: 3.0, 8.9, < .001). With respect FIGOI-IIa 6.18 [95% 1.9, 10.7] .01) but remained unchanged FIGO IIb-IV. In conclusion, increasing paralleled previously rise incidence this Given poor prognosis more studies are needed clarify underlying reason these findings.