MASS cohort: Multicenter, longitudinal, and prospective study of the role of microbiome in severe pneumonia and host susceptibility

• DOI: 10.1002/imt2.218
• Publication Date: 2024-06-25T15:24:56Z
• Authors: Xin Wei; Li Guo; Hongliu Cai; Silan Gu; Lingling Tang; Yuxin Leng; Minghui Cheng; Guojun He; Yijiao Han; Xindie Ren; Baoyue Lin; Longxian Lv; Huanzhang Shao; Mingqiang Wang; Hongyu Wang; Dan Dang; Shengfeng Wang; Nan Wang; Peng Shen; Qianqian Wang; Yinghe Xu; Yongpo Jiang; Ning Zhang; Xuwei He; Xuntao Deng; Muhua Dai; Lin Zhong; Yonghui Xiong; Yujie Pan; Kankai Tang; Fengqi Liu; Bin Yang; Lili Ren; Jianwei Wang; Chao Jiang; Lingtong Huang
• Keywords: Computer applications to medicine. Medical informatics; Correspondence; R858-859.7

The MASS cohort comprises 2000 ICU patients with severe pneumonia, covering community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia, sourced from 19 hospitals across 10 cities in three provinces. A wide array of samples including bronchoalveolar lavage fluid, sputum, feces, and whole blood are longitudinally collected throughout patients' ICU stays. The cohort study seeks to uncover the dynamics of lung and gut microbiomes and their associations with severe pneumonia and host susceptibility, integrating deep metagenomics and transcriptomics with detailed clinical data.