Comprehensive multi‐tissue epigenome atlas in sheep: A resource for complex traits, domestication, and breeding

• DOI: 10.1002/imt2.254
• Publication Date: 2024-12-15T11:28:43Z
• Authors: Deyin Zhang; Jiangbo Cheng; Xiaolong Li; Kai Huang; Lvfeng Yuan; Yuan Zhao; Dan Xu; Yukun Zhang; Liming Zhao; Xiaobin Yang; Zongwu Ma; Quanzhong Xu; Chong Li; Xiaojuan Wang; Chen Zheng; Defu Tang; Fang Nian; Xiangpeng Yue; Wanhong Li; Huibin Tian; Xiuxiu Weng; Peng Hu; Yuanqing Feng; Peter Kalds; Zhihua Jiang; Yunxia Zhao; Xiaoxue Zhang; Fadi Li; Weimin Wang
• Keywords: Epigenome; Genetic Resources

Comprehensive functional genome annotation is crucial to elucidate the molecular mechanisms of agronomic traits in livestock, yet systematic sheep lacking. Here, we generated 92 transcriptomic and epigenomic data sets from nine major tissues, along with whole-genome 2357 individuals across 29 breeds worldwide, 4006 phenotypic related tail fat weight. We constructed first multi-tissue epigenome atlas terms elements, chromatin states, their functions explored utility elements interpreting variation during domestication improvement. Particularly, identified a total 753,723 nonredundant over 60% being novel. found tissue-specific promoters enhancers sensory abilities immune response that were highly enriched genomic regions influenced by domestication, while