Effects of reactive oxygen species and antioxidant strategies on wound healing in diabetes

• DOI: 10.1002/inmd.20240062
• Publication Date: 2025-03-19T04:34:22Z
• Authors: Qiuyi Yu; Zijun Zheng; Huihui Zhang; Erlian Xie; Lianglong Chen; Ziwei Jiang; Yanbin Gao; Jun Ma; Lei Yang

Abstract With the rising global prevalence of diabetes, rate chronic wounds associated with this disease is also escalating. Although mechanisms underlying trend are not fully understood, accumulating evidence suggests a critical role for reactive oxygen species (ROS). Increased blood glucose levels, bacterial infections, and impaired energy utilization lead to an imbalance between oxidative antioxidant responses, resulting in ROS accumulation. The cellular system can manage small amount ROS; however, excessive exogenous acts upon cell membrane or even penetrates cell, consequently affecting its activity. Excessive cause enhanced expression inflammatory factors, proliferation, vascular vessel damage, extracellular matrix remodeling disturbance, ultimately hindering diabetic wound healing. regulation during healing intricate involves diverse throughout entire wound‐healing process. This review provides systematic overview relationship signaling pathways along most recent strategies targeting these pathways. aim was outline effective mitigating stress provide novel insights into future research.