Aquaporin‐5 is expressed in adipocytes with implications in adipose differentiation

• DOI: 10.1002/iub.1345
• Publication Date: 2015-01-29T05:07:24Z
• Authors: Ana Madeira; Andreia F. Mósca; Teresa F. Moura; Graça Soveral
• Keywords: 3T3-L1

Abstract Aquaporins (AQPs) are membrane channels widely distributed in nature. Typically, multiple isoforms expressed a single tissue. The adipose tissue is no exception where several AQP members have been identified. importance of overlapped AQPs expression unclear, yet interisoforms interactions might be required for key cellular functions. Recently, AQP5 was described as regulator other isoforms. Therefore, we hypothesized role adipocyte biology. Gene analysis revealed the presence both 3T3‐L1 fibroblasts and adipocytes, being more abundant later. depletion impaired differentiation, which confirmed by decreased specific differentiation markers. By overexpressing human mature adipocytes it possible to ascertain its water channel gain‐of‐function scenario. To our knowledge, this first time that reported on Our data new player © 2015 IUBMB Life, 67(1):54–60,