A hypothesis concerning the role of PPAR family on cardiac energetics in Adriamycin‐induced cardiomyopathy

• DOI: 10.1002/jat.4374
• Publication Date: 2022-08-10T00:28:00Z
• Authors: Uma Priya Mohan; Tirupathi Pichiah PB; Selvaraj Kunjiappan; Sankarganesh Arun...
• Keywords: Molecular Docking Simulation; PPAR gamma; 0303 health sciences; 03 medical and health sciences; Doxorubicin; Iron; Humans; Myocytes, Cardiac; Cardiomyopathies; Heme Oxygenase-1; Sulfur; 3. Good health

Adriamycin is an effective anti-neoplastic drug against a variety of cancer types. However, the causes adverse side effects in number organ systems. Cardiomyopathy one life-threatening Adriamycin. In current work, we have derived hypothesis with possible involvement PPAR family members development Adriamycin-induced cardiomyopathy. Dysregulation by impairment transport and β-oxidation fatty acids, key substrate for ATP synthesis heart. Evidences suggest that dysregulation alters recruitment glucose transporters. Furthermore, heme oxygenase-1 crucial enzyme regulating iron homeostasis heart whose expression regulated family. Inverse relationship exists between levels PPARγ oxygenase-1. upregulates which turn disrupts cardiomyocytes. Our molecular docking results show has high affinity iron-binding sites oxygenase-1, thereby hindering formation iron-sulfur complex. The lack complex impairs electron chain. addition, succinate dehydrogenase subunit A downregulated this uncouples Krebs cycle from ETC. Further, increases concentration succinate, further mitochondrial membrane potential. Overall, present hypothesize alteration major metabolic chaos oxidative stress caused during