Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications

• DOI: 10.1002/jbio.201100112
• Publication Date: 2012-03-22T21:15:54Z
• Authors: Liubov A. Osminkina; Konstantin P. Tam...; Andrey P. Sviridov; Rostislav A. Galkin; Maxim B. Gongalsky; Valery V. Solovyev; Andrey A. Kudryav...; Victor Yu. Timosh...
• Keywords: Porous Silicon; Biocompatible material

Abstract Silicon nanoparticles (SiNPs) obtained by mechanical grinding of porous silicon have been used for visualization living cells in vitro . It was found that SiNPs could penetrate into the without any cytotoxic effect up to concentration 100 μg/ml. The cell cytoplasm observed be filled SiNPs, which exhibited bright photoluminescence at 1.6 eV. also act as photosensitizers singlet oxygen generation, photodynamic therapy cancer. These properties are discussed view possible applications theranostics (both and diagnostics). (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)