Observation of an improved healing process in superficial skin wounds after irradiation with a blue‐LED haemostatic device

• DOI: 10.1002/jbio.201500191
• Publication Date: 2016-01-12T14:23:18Z
• Authors: Riccardo Cicchi; Francesca Rossi; Domenico Alfieri; Stefano Bacci; Francesca Tatini; Gaetano De Siena; Gaia Paroli; Roberto Pini; Francesco S. Pavone
• Keywords: 0301 basic medicine; Light; General Physics and Astronomy; wound healing; General Biochemistry, Genetics and Molecular Biology; Hemostatics; Thermal effects; Rats, Sprague-Dawley; 03 medical and health sciences; Animals; General Materials Science; European Commission; blue light-emitting diodes; Skin; FP7; Wound Healing; EC; SP1-Cooperation; General Engineering; General Chemistry; Information and Communication Technologies; Phototherapy; Rats; 3. Good health; Thermal effects, blue light-emitting diodes, photocoagulation, wound healing; photocoagulation

The healing process of superficial skin wounds treated with a blue-LED haemostatic device is studied. Four mechanical abrasions are produced on the back of 10 Sprague Dawley rats: two are treated with the blue-LED device, while the other two are left to naturally recover. Visual observations, non-linear microscopic imaging, as well as histology and immunofluorescence analyses are performed 8 days after the treatment, demonstrating no adverse reactions neither thermal damages in both abraded areas and surrounding tissue. A faster healing process and a better-recovered skin morphology are observed: the treated wounds show a reduced inflammatory response and a higher collagen content. Blue LED induced photothermal effect on superficial abrasions.