Histological and biochemical effects of preventive and therapeutic vascular photobiomodulation on rat muscle injury

• DOI: 10.1002/jbio.202100271
• Publication Date: 2022-01-03T11:29:26Z
• Authors: Talita Christine ...; Tainá Caroline do...; Maria Fernanda Se...; Erna Elisabeth Bach; Daniela Teixeira ...; Edgar Matias Bach Hi; Cristiane Miranda...; Sandra Kalil Buss...; Raquel Agnelli Me...; Kristianne Porta ...
• Keywords: 0301 basic medicine; 03 medical and health sciences; Muscles; Animals; Edema; Lactic Acid; Low-Level Light Therapy; Rats; 3. Good health

Abstract The intravascular or transcutaneous application of photobiomodulation (PBM) over blood vessels (vascular photobiomodulation, VPBM) has been used for the treatment inflammatory and chronic conditions with promising systemic results. This study evaluated VPBM effects on a model muscle regeneration after acute injury compared outcomes preventive therapeutic VPBM. Transcutaneous was administered rat's main tail vein. Serum levels creatine kinase (CK), aspartate aminotransferase (AST), lactate were muscles processed macroscopic microscopic analysis. Preventive led to decreased infiltrate, edema, myonecrosis but an increase in immature fibers. CK, AST, lower groups treated (lowest concentrations application). capable exerting positive effect repair, more accentuated results when administered.