Bone growth in rapid prototyped porous titanium implants

• DOI: 10.1002/jbm.a.31468
• Publication Date: 2007-09-17T18:48:08Z
• Authors: M. A. Lopez‐Heredia; E. Goyenvalle; E. Aguado; P. Pilet; C. Leroux; M. Dorget; P. Weiss; P. Layrolle
• Keywords: Titanium; Bone Development; Bone Regeneration; Time Factors; NCMLS 1: Immunity, infection and tissue repair; 02 engineering and technology; Implants, Experimental; Bone Substitutes; Materials Testing; Animals; Rabbits; 0210 nano-technology; Porosity

AbstractTwo porous titanium implants with a pore size diameter of 800 and 1200 μm (Ti800 and Ti1200) and an interconnected network were manufactured using rapid prototyping. Their dimensions and structure matched those of the computer assisted design. The porosity of the implants was around 60%. Their compressive strength and Young's modulus were around 80 MPa and 2.7 GPa, respectively. These values are comparable to those of cortical bone. The implants were implanted bilaterally in the femoral epiphysis of 15 New Zealand White rabbits. After 3 and 8 weeks, abundant bone formation was found inside the rapid prototyped porous titanium implants. For the Ti1200 implants, bone ingrowth was (23.9 ± 3.5)% and (10.3 ± 2.8)%, respectively. A significant statistical difference (p < 0.05) was found for bone ingrowth in the Ti1200 between the two delays. The percentage of bone directly apposited on titanium was (35.8 ± 5.4)% and (30.5 ± 5.0)%. No significant difference was found for bone‐implant contact between the different time periods and pore sizes. This work demonstrates that manufacturing macroporous titanium implants with controlled shape and porosity using a rapid prototyping method is possible and that this technique is a good candidate for orthopedic and maxillofacial applications. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008