Evaluation of the immunogenicity and cell compatibility of avian collagen for biomedical applications

• DOI: 10.1002/jbm.a.32616
• Publication Date: 2009-09-23T17:38:18Z
• Authors: Yong Y. Peng; Veronica Glattauer; John A. M. Ramshaw; Jerome A. Werkmei...
• Keywords: Pepsin; Biomaterial

Abstract There have been concerns regarding the suitability of bovine collagen as a biomaterial since emergence spongiform encephalopathy. Consequently, collagens from other species may be used if they can meet appropriate standards, including negligible or lack immunogenicity. In this study, potential immunogenicity both monomeric and pepsin‐solubilized chicken compared with commercial, that is approved for biomedical implantation. All were poor immunogens ovalbumin. No IgE responses detected in sera three strains mice, no hypersensitivity reactions found guinea pigs maximization Buehler tests. IgG 1 antibodies although titre was substantially lower than against mice rabbits only when immunizations performed adjuvant, after multiple injections over long period time. The response less collagens. Collagen sponges prepared two preparations supported attachment growth mouse fibroblasts. These data indicate collagen, particularly monomeric, useful certain applications. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010