Trabecular Bone Score (TBS) Predicts Vertebral Fractures in Japanese Women Over 10 Years Independently of Bone Density and Prevalent Vertebral Deformity: The Japanese Population-Based Osteoporosis (JPOS) Cohort Study

• DOI: 10.1002/jbmr.2048
• Publication Date: 2013-07-22T06:14:51Z
• Authors: Masayuki Iki; Junko Tamaki; Eiko Kadowaki; Yuho Sato; Namiraa Dongmei; Renaud Winzenrieth; Sadanobu Kagamimori; Yoshiko Kagawa; Hideo Yoneshima
• Keywords: Trabecular bone score; Spinal Deformity

ABSTRACT Bone strength is predominantly determined by bone density, but microarchitecture also plays an important role. We examined whether trabecular score (TBS) predicts the risk of vertebral fractures in a Japanese female cohort. Of 1950 randomly selected women aged 15 to 79 years, we analyzed data from 665 50 years and older, who completed baseline study at least one follow-up survey over 10 had no conditions affecting metabolism. Each included spinal imaging dual-energy X-ray absorptiometry (DXA) for fracture assessment spine areal mineral density (aBMD) measurement. TBS was obtained DXA scans archived study. Incident when height reduced 20% or more satisfied McCloskey-Kanis criteria Genant's grade 2 follow-up. Among eligible (mean age 64.1 ± 8.1 years), 92 suffered incident (16.7/103 person-years). These were older with lower aBMD values relative those without fractures. The unadjusted odds ratio standard deviation decrease 1.98 (95% confidence interval [CI] 1.56, 2.51) remained significant (1.64, 95% CI 1.25, 2.15) after adjusting aBMD. area under receiver operating characteristic curve combined 0.700 prediction not significantly greater than that alone (0.673). However, reclassification improvement measures indicated improved accuracy compared alone. Further inclusion prevalent deformity model prediction, model. Thus, associated higher independently clinical factors including deformity. could effectively improve settings. © 2014 American Society Mineral Research.