Pamidronate Attenuates Muscle Loss After Pediatric Burn Injury

• DOI: 10.1002/jbmr.2162
• Publication Date: 2013-12-18T11:30:43Z
• Authors: Elisabet Børsheim; David N Herndon; Hal K Hawkins; Oscar E Suman; Matthew Cotter; Gordon L Klein
• Keywords: Pediatric burn

ABSTRACT Children who are burned >40% total body surface area lose significant quantities of both bone and muscle mass because acute resorption, inflammation, endogenous glucocorticoid production, which result in negative nitrogen balance. Because administration the bisphosphonate pamidronate within 10 days burn injury completely prevents loss, we asked whether protein balance was altered by preservation bone. We reviewed results from 17 pediatric subjects previously enrolled a double-blind randomized controlled study prevention post-burn loss were concurrently evaluated for synthesis breakdown stable isotope infusion studies during hospitalization. found significantly lower fractional rate (FSR) group correspondingly appearance amino acid tracer venous blood, suggesting turnover. Moreover, net (synthesis minus breakdown) positive receiving those placebo. Muscle fiber diameter greater leg strength at 9 months not different between received normal physically fit age-matched children studied our lab. Leg served as controls tended to be weaker, although so. If substantiated larger study, these suggest that may have paracrine mechanism preserve this finding implications treatment sarcopenia elderly. © 2014 American Society Bone Mineral Research.