WNT5A Has Anti-Prostate Cancer Effects In Vitro and Reduces Tumor Growth in the Skeleton In Vivo

• DOI: 10.1002/jbmr.2362
• Publication Date: 2014-09-15T19:11:39Z
• Authors: Stefanie Thiele; Andy Göbel; Tilman D Rachner; Susanne Fuessel; Michael Froehner; Michael H Muders; Gustavo B Baretton; Ricardo Bernhardt; Franz Jakob; Claus C Glüer; Martin Bornhäuser; Martina Rauner; Lorenz C Hofbauer
• Keywords: Skeleton (computer programming); WNT5A

ABSTRACT Prostate cancer is the most frequent malignancy in men, and a major cause of prostate cancer–related death attributable to bone metastases. WNT5A known influence clinical outcome various types, including cancer, but exact mechanisms remain unknown. The goal this study was assess relevance for development progression cancer. expression determined cDNA tissue microarray primary tumor samples well-defined cohorts patients with Compared benign tissue, its receptor Frizzled-5 higher above median had probability survival after 10 years. Using different osteotropic human cell lines, overexpression knock-down on proliferation, migration, apoptosis assessed. In vitro, induced reduced proliferation whereas showed opposite effects. vivo, xenograft models were used determine effects growth. Local growth microenvironment considerably diminished PC3 cells. exhibits antitumor cells may be suitable as prognostic marker therapeutic target associated skeletal © 2014 American Society Bone Mineral Research.