VEGF gene rs3025039C/T and rs833052C/A variants are associated with bladder cancer risk in Asian descendants

• DOI: 10.1002/jcb.28324
• Publication Date: 2019-01-04T18:47:27Z
• Authors: Li‐Feng Zhang; Ke‐Wei Ren; Li Zuo; Jian‐Gang Zou; Ning‐Hong Song; Yuan‐Yuan Mi; Zeng‐Jun Wang; Wei Zhang
• Keywords: Survival Rate; Vascular Endothelial Growth Factor A; 03 medical and health sciences; 0302 clinical medicine; Asian People; Urinary Bladder Neoplasms; Risk Factors; Case-Control Studies; Humans; Genetic Predisposition to Disease; Prognosis; Polymorphism, Single Nucleotide; 3. Good health

AbstractIntroductionPolymorphisms of vascular endothelial growth factor (VEGF) gene were evaluated in a number of studies to evaluate bladder cancer (BCa) susceptibility but with controversial conclusions.Material and MethodsWe performed a pooled analysis and used odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) to investigate the correlation between VEGF gene rs3025039C/T and rs833052C/A variants and risk of BCa. Furthermore, we utilized in silico tools to demonstrate the relationship of VEGF expression correlated with BCa susceptibility and survival time.ResultsA total of eight studies including 4359 BCa patients and 5417 control subjects were enrolled in our study. For VEGF rs3025039C/T, a significant association was indicated between this variant and BCa risk in homozygote comparison (OR = 1.51; 95% CI = 1.13‐2.02; P heterogeneity = 0.815) and recessive genetic model (OR = 1.49; 95% CI = 1.12‐1.99; P heterogeneity = 0.874), in particular in an Asian population subgroup. For VEGF rs833052C/A, we observed a positive association between this variant and BCa susceptibility in Asian descendants. Results from in silico tool showed evidence that VEGF expression in bladder carcinoma tissue is higher than that in normal counterpart (transcripts per kilobase million = 7.21 vs 6.85; P < 0.05).ConclusionsThe VEGF gene rs3025039C/T and rs833052C/A variants may contribute to the risk of developing BCa, especially in Asian descendants. Future larger sample studies should be continued to focus on this issue in more detail.