The correlation of lncRNA SNHG16 with inflammatory cytokines, adhesion molecules, disease severity, and prognosis in acute ischemic stroke patients

• DOI: 10.1002/jcla.24439
• Publication Date: 2022-04-20T08:44:52Z
• Authors: Chen Xie; Bin Zhu; Juxian Gu; Muhua Sun
• Keywords: Pathogenesis; Proinflammatory cytokine; Pathophysiology

Long non-coding RNA small nucleolar host gene 16 (lncRNA SNHG16) is involved in the pathogenesis of acute ischemic stroke (AIS) through regulation brain endothelial cell viability, inflammation, atherosclerotic plaque formation, and neural apoptosis. This study aimed to evaluate prognostic value lncRNA SNHG16 AIS patients. Newly diagnosed patients (N = 120) were serially recruited. Their expressions peripheral blood mononuclear cells (PBMCs) detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR); serum inflammatory cytokines adhesion molecules determined using enzyme-linked immunosorbent assay (ELISA). The accumulating recurrence-free survival (RFS) overall (OS) analyzed. Moreover, controls 60) recruited their PBMCs detected. LncRNA was declined compared (p < 0.001). not related any comorbidities (all p > 0.05). Interestingly, negatively tumor necrosis factor alpha (TNF-α) 0.001), interleukin 6 (IL-6) 0.013), intracellular molecule-1 (ICAM-1) 0.024), while positively correlated with 10 (IL-10) 0.022) Besides, inversely associated National Institutes Health Stroke Scale (NIHSS) score 0.003). During follow-up period, 14 (11.7%) occurred recurrence 5 (4.2%) died. Unexpectedly, RFS 0.103) or OS 0.150) relates lower cytokines, molecules, milder disease severity, but fails predict prognosis