LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR‐335‐5p

• DOI: 10.1002/jcp.27484
• Publication Date: 2018-10-26T11:24:09Z
• Authors: Huiling Liang; Chunyan Zhang; Hongya Guan; Jia Liu; Yuanbo Cui
• Keywords: ROCK1; Competing Endogenous RNA; Tumor progression

Abstract Emerging evidence highlights the key regulatory roles of long noncoding RNAs (lncRNAs) in initiation and progression numerous malignancies. The lncRNA identified as differentiation antagonizing nonprotein coding RNA (DANCR) is a novel widely involved development multiple human cancers. However, function DANCR its potential molecular mechanism cervical cancer remain unclear. In this study, we discovered that was significantly elevated tissues cells, closely correlated with poor prognosis patients. addition, knockdown inhibited proliferation, migration, invasion cells vitro, indicating functioned an oncogene cancer. Moreover, verified could directly bind to miR‐335‐5p, isolating miR‐335‐5p from target gene Rho‐associated coiled‐coil containing protein kinase 1 (ROCK1). Functional analysis showed regulated ROCK1 expression by competitively binding miR‐335‐5p. Further cellular behavioral experiments revealed mimics reversed effects upregulated on invasion, epithelial‐mesenchymal transition (EMT) rescue assays. summary, study demonstrated promoted functioning competing endogenous (ceRNA) regulate via sponging suggesting therapeutic for