Cholinergic anti‐inflammatory pathway confers airway protection against oxidative damage and attenuates inflammation in an allergic asthma model

• DOI: 10.1002/jcp.29101
• Publication Date: 2019-07-23T04:04:31Z
• Authors: Géssica Luana Ant...; Josiane Silva Sil...; Daniela Benvenutt...; Carolina Luft; Mariana Severo da...; Eduardo Peil Marques; Fernanda Silva Fe...; Ricardo Vaz Breda; Angela T. S. Wyse; Renato Tetelbom S...; Paulo Márcio Pitrez; Aline Andrea da C...
• Keywords: Allergic Inflammation

Abstract Asthma is characterized by the influx of inflammatory cells, especially eosinophils as well reactive oxygen species (ROS) production, driven release T helper 2 (Th2)‐cell‐associated cytokines. The cholinergic anti‐inflammatory pathway (CAP) inhibit cytokines production and controls inflammation. Thus, we investigated effects pharmacological activation CAP neostigmine on oxidative stress airway inflammation in an allergic asthma model. After OVA challenge, mice were treated with neostigmine. We showed that reduced levels pro‐inflammatory (IL‐4, IL‐5, IL‐13, IL‐1β, TNF‐α), which resulted a decrease influx. Furthermore, also conferred protection against stress, attenuating ROS through increase antioxidant defense, evidenced catalase (CAT) activity. propose, for first time, can lead to new possibilities therapeutic management asthma.