Retracted: lncRNA PVT1 promotes the migration of gastric cancer by functioning as ceRNA of miR‐30a and regulating Snail

• DOI: 10.1002/jcp.29881
• Publication Date: 2020-06-19T05:37:02Z
• Authors: Lina Wang; Bin Xiao; Ting Yu; Li Gong; Yu Wang; Xiaokai Zhang; Quanming Zou; Qianfei Zuo
• Keywords: PVT1; Competing Endogenous RNA

Abstract Although the incidence and mortality of gastric cancer (GC) are slowly decreasing, overall prognosis GC patients with distal metastasis remains dismal. Long non‐coding RNA PVT1 has been verified to function as a tumor promoter in several types cancer. However, role obscure. Herein, we found that was highly expressed tissues high level associated stage, lymph node metastasis, poor prognosis. Overexpression significantly elevated epithelial‐to‐mesenchymal transition (EMT) marker (N‐cadherin, ZEB1, ZEB2) levels promoted cell EMT process vitro vivo. Mechanistically, Snail identified direct target miR‐30a. could bind miR‐30a increase expression by acting competing endogenous RNA, whereas re‐expression cells rescued markers, decreased level, inhibited migration. Taken together, these findings provide new light on pathogenesis development an important implication for future therapy GC.