Cell therapy for fibrotic interstitial pulmonary disease: Experimental study

• DOI: 10.1002/jemt.20981
• Publication Date: 2011-01-04T21:05:17Z
• Authors: Rosa M. Cabral; ÉRIKA BRANCO; Márcia Dos S. Rizzo; Guilherme J. Ferr...; Guilherme B. Greg...; Vivian Y. Samoto; Ângelo J. Stopiglia; Paulo C. Maiorka; Emerson T. Fioretto; Vera L. Capelozzi; João B. Borges; Susimeire Gomes; Marcelo A. Beraldo; Carlos R. R. Carv...; Maria A. Miglino
• Keywords: Parenchyma; Histology; Mononuclear cell infiltration

Abstract Parte superior do formulário Digite um texto ou endereço de site traduza documento. The aim of this study is to evaluate the histological changes in lung parenchyma pigs affected by interstitial disease induced after infusion bone marrow mononuclear cells (BMMCs). Ten female swines were submitted pulmonary fibrosis a single dose intratracheal bleomicine sulfate. Animals arranged into two groups: Group 1: induced‐disease control and 2: cell therapy using BMMCs. Both groups clinically evaluated for 180 days. High‐resolution computed tomography (HRCT) was performed at 90 BMMC sampling group Euthanasia performed, samples collected histology immunohistochemistry. 90‐days HRCT demonstrated typical lesions similarly human disease. 180‐days 1 advanced stages when compared with 2. Immunohistochemistry analysis suggests presence pre‐existent vessels neoformed as well predominant young injured that would promote reconstructive response. Histology suggest positive application swine model inducing fibrotic Microsc. Res. Tech., 2011. © 2011 Wiley‐Liss, Inc.