Prognostic value of postinduction medullary myeloid recovery by flow cytometry in acute myeloid leukemia

• DOI: 10.1002/jha2.822
• Publication Date: 2024-01-11T07:04:16Z
• Authors: Céline Row; Nicolas Lechevalier; Jean Philippe Vial; Aguirre Mimoun; Jean Noel Bastie; Ingrid Lafon; Arnaud Pigneux; Thibaut Leguay; Mary Callanan; Marc Maynadie; Marie C. Béné; Pierre Yves Dumas; Julien Guy
• Keywords: Log-rank test; Minimal Residual Disease; NPM1

Risk stratification and treatment response evaluation are key features in acute myeloid leukemia (AML) management. Immunophenotypic molecular approaches all rely on the detection of persisting leukemic cells by measurable residual disease techniques. A new approach is proposed here assessing medullary maturation flow cytometry through a progenitor ratio (MPR). The normal MPR range was defined using reference bone marrows (