Copper‐Catalyzed N‐Arylation of Polysubstituted Pyridines Synthesized by the Novel Reaction of N‐Sulfonyl Ketenimine and Malononitrile‐Trichloroacetonitrile Adduct

• DOI: 10.1002/jhet.3668
• Publication Date: 2019-08-15T02:09:47Z
• Authors: Manijeh Nematpour; Hossein Fasihi Da...; Sayyed Mohammad I...; Sayyed Abbas Taba...
• Keywords: Ketenimine; Sulfonyl; Tetrahydrofuran

In this study, we synthesized some new derivatives of N ‐(4‐amino‐5‐cyano‐6‐(trichloromethyl)pyridin‐2‐yl)alkyl sulfonamides in the presence a copper catalyst. A one‐pot reaction system was used, and four components participated process. These were sulfonyl azides, terminal alkynes, malononitrile, trichloroacetonitrile. The rate increased by use (I) iodide as catalyst tetrahydrofuran used solvent. We achieved final compounds moderate to good yields. Moreover, converted “NH 2 ” side group ‐aryl various aryl halide analogs acetonitrile solvent, under mild at room temperature.