The relation between dietary polysaccharide intake and urinary excretion of tetraglucoside

• DOI: 10.1002/jimd.12801
• Publication Date: 2024-10-26T08:58:18Z
• Authors: Candelas Gross‐Valle; Tessa C. Jacobs; Janneke D. A. Dij...; Janniek Lubberts; Barbara M. Bakker; Stephan J. L. Bakker; Yvonne van der Veen; Andrea B. Schreuder; Terry G. J. Derks; Jennifer van der ...; Joost Groen; M. Rebecca Heiner...
• Keywords: biological variation; tetraglucoside; glycogen storage diseases; biomarkers; Original Article; glycogen metabolism; glucose tetrasaccharide

The urinary metabolite tetraglucoside (Glc4) is a potential biomarker for hepatic glycogen storage diseases (GSDs). Glc4 believed to reflect body content and/or turnover. However, dietary polysaccharide intake may influence excretion, potentially limiting the utility of as monitoring in GSDs. We aimed investigate association with excretion. Urinary excretion (mmol/mmol creatinine and mmol/24 h) was analyzed using validated LC-MS/MS method. Data from 65 kidney transplant recipients 58 healthy donors TransplantLines cohort study. Spearman's correlation multivariable linear regression analyses were performed. In analysis, dry lean mass (DLBM), intake, transplantation status, age, sex, glycated hemoglobin (HbA1c) served independent variables. Daily variation examined 21 individuals 2-h collections over 24-h period. Mixed generalized additive models built study prior No (univariate) associations found between significant interaction DLBM on 24 h observed multivariate analysis. throughout day exhibited no relationship intake. Our findings suggest an indirect effect due changes muscle have evidence that polysaccharides under normal intakes increase directly.