Interleukin-5 induces apoptotic defects in CD4+ T cells of patients with allergic rhinitis

• DOI: 10.1002/jlb.3a0718-287rr
• Publication Date: 2019-01-29T23:47:46Z
• Authors: Xiang-Qian Luo; Fei Ma; Shuai Wang; Mei-Zhen Zhao; Jian-Bo Shao; Xiao-Rui Geng; Jiang-Qi Liu; Li-Hua Mo; Li Guan; Zhi-Gang Liu; Da-Bo Liu; Ping-Chang Yang
• Keywords: Fas ligand; Jurkat cells; Pathogenesis

T helper (Th)2 polarization plays an important role in the pathogenesis of allergic diseases; underlying mechanism remains to be further investigated. B cell lymphoma protein-2 like protein-12 (Bcl2L12) has anti-apoptotic function. This study aims elucidate contribution Bcl2L12 Th2 patients with rhinitis (AR). In this study, human CD4+ cells were isolated from blood samples collected AR and healthy control (HC) subjects. The immune response profiles analyzed by immunologic approaches. results showed that (CD4+ patients) defects apoptosis. expression FasL was lower than HC cells. Serum IL-5 levels negatively correlated Exposure culture suppressed increased Bcl2L12. cells, latter bound promoter prevent gene transcription. Inhibition restored apoptosis machinery conclusion, overexpression compromises machinery; can inhibition BcL2L12 may a novel target for treatment other disorders.