DNA physical interaction mediated b‐lymphoma treatment offered by tetra benzimidazole‐substituted zinc (ii) phthalocyanine derivative

• DOI: 10.1002/jmr.2733
• Publication Date: 2018-06-28T05:06:42Z
• Authors: Bushra Taj Muhammad; Azeem Ullah; Munira Taj Muhammad; Tanzila Arshad
• Keywords: Benzimidazole; Derivative (finance)

Abstract Role of heterocyclic compounds with nitrogen substitution in therapeutic frontiers is well established. The efforts made this study are directed to dissect the biological significance benzimidazole‐substituted zinc phthalocyanine derivative. Its capacity act as an anticancer agent against 2 B‐lymphoma cell lines (low‐grade and high‐grade malignancy) was found out by recording florescence using Alamar blue dye. Further cytotoxic effect at DNA level analyzed performing agarose gel electrophoresis. Molecular docking studies mechanistic details crystal clear showing potential dual binding modes employed for interaction that include minor groove intercalation between bases. This advocates derivative deserves further rounds its final journey serve a marketed drug.