Apparent diffusion coefficient: Prostate cancer versus noncancerous tissue according to anatomical region

• DOI: 10.1002/jmri.21513
• Publication Date: 2008-10-03T20:08:23Z
• Authors: Jeoung Hyun Kim; Jeong Kon Kim; Bum‐Woo Park; Namkug Kim; Kyoung‐Sik Cho
• Keywords: Aged, 80 and over; Male; Prostate; Prostatic Neoplasms; Reproducibility of Results; Middle Aged; Image Enhancement; Sensitivity and Specificity; 3. Good health; 03 medical and health sciences; Diffusion Magnetic Resonance Imaging; 0302 clinical medicine; Image Interpretation, Computer-Assisted; Humans; Algorithms; Aged

Abstract Purpose To evaluate diagnostic performance of apparent diffusion coefficient (ADC) in differentiating prostate cancer from noncancerous tissue according to anatomical region. Materials and Methods In 47 patients with diffusion‐weighted‐MR (b‐value, 0 1000 sec/mm 2 ) on a 1.5 T unit, ADCs were measured three tissues (transitional zone, peripheral prostatic base). Diagnostic ADC for was evaluated using receiver‐operating‐characteristics (ROC) analysis. Results Mean (0.963 × 10 −3 mm /s) lower than those all ( P < 0.001). tissue, differed region (peripheral 1.572 /sec; transitional 1.441 base, 1.146 /sec) 0.01). 34 (72%) patients. Area under the ROC curve base (0.725) less (0.952) zones (0.906) 0.05). Sensitivity 98%; 82%; 66%) Conclusion Variable may limit detection. J. Magn. Reson. Imaging 2008. © 2008 Wiley‐Liss, Inc.