Central gland and peripheral zone prostate tumors have significantly different quantitative imaging signatures on 3 tesla endorectal, in vivo T2‐weighted MR imagery

• DOI: 10.1002/jmri.23618
• Publication Date: 2012-02-15T18:58:36Z
• Authors: Satish E. Viswanath; Nicholas B. Bloch; Jonathan C. Chapp...; Robert Toth; Neil M. Rofsky; Elizabeth M. Genega; Robert E. Lenkinski; Anant Madabhushi
• Keywords: Ex vivo

Abstract Purpose: To identify and evaluate textural quantitative imaging signatures (QISes) for tumors occurring within the central gland (CG) peripheral zone (PZ) of prostate, respectively, as seen on in vivo 3 Tesla (T) endorectal T2‐weighted (T2w) MRI. Materials Methods: This study used 22 preoperative prostate MRI data sets (16 PZ, 6 CG) acquired from men with confirmed cancer (CaP) scheduled radical prostatectomy (RP). The region‐of‐interest (ROI) was automatically delineated T2w MRI, following which it corrected intensity‐based acquisition artifacts. An expert pathologist manually dominant tumor regions ex sectioned stained RP specimens well identified each studies either a CG or PZ CaP. A nonlinear registration scheme to spatially align then map CaP extent sections onto corresponding slices. total 110 texture features were extracted per‐voxel basis all sets. information theoretic feature selection procedure applied QISes comprising specific CaP, respectively. evaluated by means Quadratic Discriminant Analysis (QDA) against ground truth mapped histology. Results: QDA classifier yielded an area under Receiver Operating characteristic curve 0.86 studies, 0.73 over 25 runs randomized three‐fold cross‐validation. By comparison, accuracy significantly lower when (a) using (with no applied), (b) randomly selected combination features. Conclusion: cancers have differing J. Magn. Reson. Imaging 2012;36:213–224. © 2012 Wiley Periodicals, Inc.