Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis

• DOI: 10.1002/jnr.1207
• Publication Date: 2002-08-25T19:53:55Z
• Authors: Romesh Stanislaus; Avtar K. Singh; Inderjit Singh
• Keywords: Lovastatin; Mononuclear cell infiltration; Encephalomyelitis; Infiltration (HVAC)

Abstract Mononuclear cell infiltration into the CNS and induction of inflammatory cytokines iNOS in diseases like multiple sclerosis (MS) experimental allergic encephalomyelitis (EAE) have been implicated subsequent disease pathogenesis progression. We report that Lovastatin treatment blocks clinical spinal cords MBP induced EAE rats. A significant number infiltrating cells were ED1+ monocyte/macrophage lineage. To understand mechanism efficacy against EAE, we examined effect on transmigration mononuclear cord. The data presented here documents attenuates possibly by down regulating expression LFA‐1, a ligand for ICAM, endothelial‐leukocyte interaction. These results indicate prevents rats thereby lessening histological changes signs thus ameliorating disease. observations may be therapeutic value process associated with activated tissue. J. Neurosci. Res. 66:155–162, 2001. © 2001 Wiley‐Liss, Inc.