Particle‐induced osteolysis is not accompanied by systemic remodeling but is reflected by systemic bone biomarkers

• DOI: 10.1002/jor.22607
• Publication Date: 2014-03-06T11:28:42Z
• Authors: R.D. Ross; A.S. Virdi; S. Liu; K. Sena; D.R. Sumner
• Keywords: Osteolysis; Bone remodeling; Sclerostin

ABSTRACT Particle‐induced osteolysis is caused by an imbalance in bone resorption and formation, often leading to loss of implant fixation. Bone remodeling biomarkers may be useful for identification studying pathogenesis, but interpretation biomarker data could confounded if local engenders systemic remodeling. Our goal was determine remote contributes levels. Serum concentrations eight rates at (femur), contiguous (tibia), (humerus lumbar vertebra) sites were evaluated a rat model particle‐induced osteolysis. CTX‐1, cathepsin K, PINP, OPG elevated osteocalcin suppressed the osteolytic group, RANKL, TRAP 5b, sclerostin not affected termination study 12 weeks. The one marker tested longitudinally (CTX‐1) 3 We found increased decreased formation locally, subtle differences sites, no remotely Thus, skeletal response particle challenge systemic, implying that observed serum levels reflect © 2014 Orthopaedic Research Society. Published Wiley Periodicals, Inc. J Orthop Res 32:967–973, 2014.