Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates

• DOI: 10.1002/jor.23211
• Publication Date: 2016-02-26T08:29:37Z
• Authors: Shimpei Kondo; Takeshi Muneta; Yusuke Nakagawa; Hideyuki Koga; Toshifumi Watanabe; Kunikazu Tsuji; Shinichi Sotome; Atsushi Okawa; Shinji Kiuchi; Hideo Ono; Mitsuru Mizuno; Ichiro Sekiya
• Keywords: Meniscus; Medial meniscus; Fibrocartilage

Transplantation of aggregates synovial mesenchymal stem cells (MSCs) enhanced meniscus regeneration in rats. Anatomy and biological properties the depend on animal species. To apply this technique clinically, it is valuable to investigate use animals genetically close humans. We investigated whether transplantation autologous MSCs promoted meniscal aged primates. Chynomolgus primates between 12 13 years old were used. After anterior halves medial menisci both knees removed, an average 14 consisting 250,000 transplanted onto defect. No opposite knee for control. Meniscus articular cartilage analyzed macroscopically, histologically, by MRI T1rho mapping at 8 (n = 3) 16 weeks 4). The was larger modified Pauli's histological score regenerated better MSC group than control each primate weeks. Mankin's femoral condyle all value adjacent closer normal delayed progression degeneration This first report dealing with © 2017 Orthopaedic Research Society. Published Wiley Periodicals, Inc. J Orthop Res 35:1274–1282, 2017.