Biofilm formation increases treatment failure in Staphylococcus epidermidis device‐related osteomyelitis of the lower extremity in human patients

• DOI: 10.1002/jor.23218
• Publication Date: 2016-03-01T12:50:39Z
• Authors: Mario Morgenstern; Virginia Post; Christoph Erichsen; Sven Hungerer; Volker Bühren; Matthias Militz; R. Geoff Richards; T. Fintan Moriarty
• Keywords: Adult; Male; 0303 health sciences; Prosthesis-Related Infections; Middle Aged; 3. Good health; 03 medical and health sciences; Phenotype; Anti-Infective Agents; Recurrence; Biofilms; Staphylococcus epidermidis; Humans; Female; Methicillin Resistance; Prospective Studies; Treatment Failure; Aged

The ability to form biofilm on the surface of implanted devices is often considered most critical virulence factor possessed by Staphylococcus epidermidis in its role as an opportunistic pathogen orthopaedic device-related infection (ODRI). Despite this recognition, there a lack clinical evidence linking outcome with forming for S. ODRIs. We prospectively collected isolates cultured from patients presenting ODRI. Antibiotic resistance patterns and biofilm-forming was assessed. Patient information treatment measures were determined after mean follow-up period 26 months. primary measure cure at follow-up. Univariate logistic regression models used determine influence formation antibiotic outcome. A total 124 included study, majority whom (n = 90) involved infections lower extremity. clear trend emerged extremity cohort whereby rates decreased increased (84% rate caused non-biofilm formers, 76% weak biofilm-formers, 60% marked p 0.076). did not rate. Chronic immunosuppression associated statistically significant decrease (p 0.044).The increasing resulting ODRI indicates infecting pathogens does © 2016 Orthopaedic Research Society. Published Wiley Periodicals, Inc. J Orthop Res 34:1905-1913, 2016.