Association between subchondral bone structure and osteoarthritis histopathological grade

• DOI: 10.1002/jor.23312
• Publication Date: 2016-05-26T17:26:41Z
• Authors: Mikko A. J. Finnilä; Jérôme Thevenot; Olli‐Matti Aho; Virpi Tiitu; Jari Rautiainen; Sami Kauppinen; Miika T. Nieminen; Kenneth Pritzker; Maarit Valkealahti; Petri Lehenkari; Simo Saarakkala
• Keywords: Subchondral bone; X-ray microtomography; Histology

Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in structure compared cartilage degeneration. This study linked structural adaptation of with histological OA grade. Twenty-five osteochondral samples macroscopically different degeneration were prepared from tibiae 14 patients. Samples scanned micro-computed tomography (μCT) and both conventional parameters novel 3D based on patterns analyzed the plate trabecular bone. Subsequently, processed for histology evaluated OARSI Each parameter grade was assess severity. In addition, thicknesses cartilage, calcified sections thickness μCT. With grade, became thicker along decreased specific surface, while there no change tissue mineral density. Histological analysis showed μCT also includes cartilage. Entropy increased severity, reflecting higher heterogeneity. compartment, volume fraction number separation model index decreased. Also, elevation longitudinal axial transverse demonstrates possibility radiological assessment severity by © 2016 The Authors. Journal Orthopaedic Research Published Wiley Periodicals, Inc. J Orthop Res 35:785-792, 2017.